Saturday, July 14, 2012

Dr. Looi Q & A - Part 1


Anti- Lynas QUOTE:
Potassium-40, when absorbed, is distributed more uniformly throughout the human body, mostly in muscle tissue which is among the least radio-sensitive of the body’s tissues, Thorium entering the bloodstream localises to the bones where it is retained with a biological half-life of 22 years

ANSWER:
When Potassium is taken into the body it is not just concentrated in the muscles but concentrated in the INTRACELLULAR spaces of ALL CELLS where the cancer sensitive chromosomes are located!

So to say that Potassium concentration is less in the radiosensitive cells of the blood, lymphoid tissues, testis, ovaries and intestine is definitely not in line with basic human physiology.

It is concentrated and equally distributed in ALL INTRACELLULAR SPACES . In terms of per cell mass, it may be slightly less only in fat cells.

Intracellular Potassium = 139 to 140 mEq 
Extracellular Potassium = 4 mEq which is tiny compared with the Intracellular Potassium.

Thorium-232 stays mainly in the extracellular space where it is not so harmful.
Practically all the data on the acute and long term toxicology of Thorium-232 comes from the study of Thorotrast.

Most of the human data for thorium exposure comes from diagnostic studies. A massive dose of 1 to 2 vials of 25 ml of 25% Colloidal thorium-232 dioxide (Thorotrast) was injected into patients as a radiographic contrast medium between 1928 and 1955. 

Thorium dioxide in Thorotrast is insoluble and in a colloidal form i.e. in the form of particles. All insoluble particles are taken up by the macrophages and other cells of the reticulo-endothelial (RE) system and deposited into the tissues of the RE system i.e. the liver, spleen, lymph nodes, bone marrow and parts of the small intestines and not just the bones.

In humans, where will the soluble and not particulate form of Thorium salts be deposited and what is the renal clearance and hence their biological half life ? Nobody really knows because, for obvious reasons, all studies done on Thorium are conducted on animals. The results are only applicable to rats, rabbits, cats and dogs !

In places like Kerala, a coastal belt in India, the concentration of Thorium-232 in the soil average about 4,000 ppm. 

The radiation at Karunagapally, Kerala has been assessed at 5 to 8 milisievert/year. In certain location on the coast, it is as high as 70 milisievert/year. 

Thorium-232 is strongly adsorbed to clay and there is no natural way it can get into the body. Even the plants and fruits do not contain any Thorium in these high Thorium areas.

The amount of Thorium in the human body is so tiny (estimated to be only 30 micrograms per body) that only extremely sophisticated equipments are able to measure the true level.

The epidemiological data from these studies show that the primary health effects of high doses of injected Thorotrast are blood disorders and liver tumours. However, these tumours and blood disorders could have been caused by the massive doses of X-rays from the rather antique X-ray machines used at that time.

Because these are contrast studies, more than 20 to 50 X-rays need to be taken and the dose is really massive. None of the studies have factored in this massive dose of X-rays as all the studies are done retrospectively.

Some evidence of increased incidence of lung, pancreatic, and haematopoietic cancers was found in workers occupationally exposed to thorium via inhalation.

However, these workers were also exposed to several other toxic agents especially Silica (SiO2) which is a group 1 carcinogen and in some cases to other radionuclides like Uranium, K-40 and Radium, so direct causation cannot be inferred. 

Inhalation of Thorium-232 by the general population like those living in the cities is practically impossible for the particles that can get into the lungs need to be between 1 to 5 microns. These tiny particles can only be found in the thorium or uranium mines or unsophisticated refineries. 

Few data are available regarding the health effects associated with low (e.g., environmental) levels of exposure from either inhalation or ingestion.

Dr Looi

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